Littler earlier beat world number one Humphries 6-4 in a thrilling quarter-final.
He was 4-3 down and Humphries’ missed attempt at triple 20 left him with a bogey number.
Littler pounced to sensationally take out 344, including a 167 finish, in six darts to level and from there he closed out for the win to move top of the table.
The Warrington-born teenager was in devastating form in his 6-3 semi-final win over Rob Cross too – taking out 167, 127 and 164 finishes all on bullseye.
Price ground out a 6-4 win over Stephen Bunting, who still remains without a win, in the quarter-finals, before producing a stunning display to blow away Michael van Gerwen 6-1 in the semi-finals.
He raced into a 5-0 lead and was looking for the first clean sweep since 2023 but Van Gerwen pinned double tops in leg six to avoid it.
Seven-time winner Van Gerwen, who beat Nathan Aspinall 6-4 in the quarter-finals, has won five of his six quarter-finals this year, but has lost every semi-final.